What causes acne?

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Acne Cause

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Treating acne breakouts require thorough understanding of its pathogenesis etiological factors and manifestations. Acne is common among teenagers, yet it could affect people over 20. Although acne is most prevalent among teenaged males, most can expect spontaneous treatment by age 25. Adult females may continue to experience acne into the adult years, sometimes beyond the age of 40. Problem skin ( skin implicated with acne ) characterizes by clogged enlarged pores, excess production of sebum and fatty inclusions , abnormal bacterial function and production of inflammation in acne lesions.

Role of different factors in development of acne

Acne is a multifactorial disease. Genetic, racial, hormonal, dietary and envrionmental factors have been implicated in its development, while it is clear that its psychological implications may be severe. Although the role of heredity in acne has not been clearly denied, there is a great tendency toward more serious involvement if one or both parents had severe acne during their youth.

Hormonal factors and acne : Hormones, androgen, are obviously among the causes. Sebaceous glands ( part of sebaceous follicles ) are extremely sensitive to androgenic stimulation, and their enlargement usually precedes other obvious signs of puberty even before any sign of acne. They are under endocrine control and so it is not surprising that sebum production varies with age and sex. Increase in sebum production is associated with increase in free fatty acids rather than an increase in essential fatty acids. Males have a signficantly greater sebum production than females. The sebum production continues to increase after puberty, reaching a peak in both sexes between 30 and 40 years, and thereafter there is a gradual decline. It is evident that the sebaceous gland is an androgen target organ and any measure pharmacologically to control androgens is a logical approach to treatment of acne.

Emotional factors and acne : As with any disease whose course is prolonged and capricious, the importance of psychological factors in treament of breakouts has been repeatedly stressed and should be seriously taken into account when using topical treatments. There seems to be no doubt that stressful situations such as final examinations regularly causes acne exacerbations in patients. This is probably the result of increased glucocorticoid secretion by the adrenal glands that seem to potentiate the effect of androgens.

Environmental factors and acne : Environmental factors also play a major role in determining the severity and extent of acne and affect topical treatments. In most cases the manifestations are worse in winter and improves during the summer, suggesting a salutary effect of sunlight. However, in some cases exposure to sunlight worsens the disease. The constant friction caused by protective devices such as a helmet, shoulder pads or pillows will make its management futile.

How acne develepos in the skin, acne pathogenesis

Acne is a complex, multifactorial disease whose pathogenesis proceeds according to the following scenario: Because of the influence of androgens, the sebaceous gland enlarges and quantity of sebum excretion increases. Some studies suggest hyperkeratosis preceeds activation of propionobacterium acne and cytokine activation. Follicular hyperkeratosis and increase in sebum secretion are both involved in comedone formation.

Lipases, proteases and hyaluronidases derived from resident bacteria within the pilosebaceous apparatus hydrolyze triglycerides produced by the sebaceous gland into glycerol and free fatty acids. These irritating substances cause hyperkeratination of the follicular wall, leading to obstruction and subsequent rupture. This, in turn, leads to a variable degree of inflammation resulting in the formation of pustules, papules, nodules, and cysts. The severity of the process is presumably determined by as yet unidentified genetic factors.

Accumulation of lipid peroxide and free radicals is seen with progression of acne vulgaris. This observation substantiates role of anti oxidants in prevention of comedogensis and treatment of acne.

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These choices of topical agents have been selected based on a number of criteria: efficacy in addressing the subclinical microcomedo, which is the precursor lesion for both comedones and inflammatory lesions; tolerability, due to the need for application to a broader epidermal surface; and other properties that may enhance adherence. Patients may be more motivated to use agents that are easily integrated into their lifestyles and that have potential "skin-repairing" properties.

Skin-Repairing Effects of Hippocrates maintenance treatment. Acne causes disruptions in the epidermal barrier. Such barrier defects can be associated with transepidermal water loss and an increased potential for exposure to environmental irritants. This preventing treatment takes advantage of certain skin repairing agents provide to motivate patients to continue using this treatment agents in the absence of visible lesions.

This preventive treatment help normalize the hyperkeratosis process to resolve lesions. Symptoms such as erythema, dryness and scaling occur especially early in therapy but subside with continued use. This preventive treatment kit provide the skin with natural agents with anti-inflammatory effects and robust antioxidant effects.

Its resurfacing effect helps peeling the skin and therefore minimizes acne caused lesions. Skin resurfacing is the same method used in laser treatments for acne caused skin damages.

These properties may attenuate skin damage. Adding a high-potency vitamin C serum can help with synthesis of collagen, a mechanism that partially accounts for this treatment kit efficacy in the treatment of photodamage.

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